Rome, Italy

There are many places around the world that I would love to see during my life.  The streets of Paris, London, and Moscow are all on my to see list.  Walking along the Great Wall of China and through the ruins of Machu Pichu would be events not many get to experience.  But if I could only visit one place, it would be the city of Rome.  Although Rome doesn't have a warming beach or towering mountains, it is one of the most beautiful and historically important cities on the planet.
Rome has so many things to offer.  Michelangelo, one of history's most well known artists, created many of his masterpieces in ancient Rome, and they can be seen in museums and cathedrals throughout the city. There are several things to do, however, f I ever do get the chance to visit Rome, the first thing I would do is visit the Ancient Colosseum.  From epic stories about the Roman Empire, no monument matches the Colosseum in history or beauty.  The world's first larger than life sporting arena, remnents of the once vast Colosseum are still intact today, and the thought of ancient gladiator's fighting to the death in that arena is one of the most powerful feelings one can experience.
While in Rome, you can fully indulge in Italy's most well known contribution to the culinary world, pizza.  Some of the country's best pizzeria's are located within Rome.  If pizza isn't your thing, Rome also offers some of the world's best pasta, and Italy's dessert, gelato.
Not to be forgotten is the city within the city.  If you were to somehow grow tired of Rome, one of the most holy sites in the world lies within this majestic city.  The Vatican City, home to the Pope, and perhaps the site of greatest historical importance to the Catholic Church, lies within the city of Rome. 
The only bad thing about this once in a lifetime trip would be getting there.  A flight from Boston to Rome has a duration of just over 7 hours, and would run you about $1200.  Once in Rome, staying at the city's finest hotels could max out at over $1000 per night.  Of course, much more moderate accommodations can always be made.